Medical Policy: 07.01.41
Original Effective Date: May 2008
Reviewed: March 2018
Revised: March 2018
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services were rendered. Exclusions, limitations or exceptions may apply. Benefits may vary
based on contract, and individual member benefits must be verified. Wellmark determines medical
necessity only if the benefit exists and no contract exclusions are applicable. This medical
policy may not apply to FEP. Benefits are determined by the Federal Employee Program.
This Medical Policy document describes the status of medical technology at the time the document
was developed. Since that time, new technology may have emerged or new medical literature may
have been published. This Medical Policy will be reviewed regularly and be updated as scientific
and medical literature becomes available.
Pulsed radiofrequency (PRF) is a non-ablative alternative to non-pulsed or continuous radiofrequency ablation (RFA) in the treatment of a variety of pain syndromes including but not limited to the following chronic back and neck pain, trigeminal neuralgia, post herpetic neuralgia and complex regional pain syndrome/reflex sympathetic dystrophy. Pulsed radiofrequency uses short bursts of radiofrequency current (heat is dissipated during the silent period), rather than a continuous current. The heat from pulsed radiofrequency is not enough to cause the tissue to coagulate. Pulsed radiofrequency causes the transmission across small unmyelinated nerve fibers to be disrupted, but not permanently damaged. This is because the temperature will not exceed 42°C, versus 80°C reached in non-pulsed or continuous radiofrequency ablation (RFA). Pulsed radiofrequency has been proposed as a possibly safer alternative to non-pulsed or continuous RFA.
Current available evidence on the effectiveness of pulsed radiofrequency (PRF) in the treatment of patients with various chronic pain syndromes is largely based on retrospective, case series studies. While some studies may have shown promising results for certain chronic pain syndromes, numerous studies yielded concerns about procedural protocols, study quality and patient follow up. Further well-designed, randomized controlled clinical trials with large sample size and long-term follow-up are needed to determine the therapeutic effect and safety of this treatment modality. Also, there currently is a lack data comparing pulsed radiofrequency with conventional treatments, and it is not known if pulsed radiofrequency offers any treatment advantage over other conventional treatments. In addition, there are no clinical practice guidelines from U.S. professional societies that recommend the use of pulsed radiofrequency. Per the 2013 ASIPP (American Society of Interventional Pain Physicians), their guidelines state "the evidence is limited for pulsed radiofrequeny in the treatment of chronic spinal pain." The evidence is insufficient to determine the safety and efficacy of pulsed radiofrequency (PRF) and is considered investigational for the treatment of pain from any cause.
Practice Guidelines and Position Statements
American Society of Interventional Pain Physicians
In 2013, American Society of Interventional Pain Physicians (ASIPP) published an updated guideline on interventional techniques in the management of chronic spinal pain Part II guidance and recommendation which states the following:
- Lumbar spine
- The evidence for therapeutic facet joint interventions is good for conventional radiofrequency, limited for pulsed radiofrequency, fair to good for lumbar facet joint nerve blocks, and limited for intraarticular injections.
- For sacroiliac interventions, the evidence for cooled radiofrequency neurotomy is fair; limited for intraarticular injections and periarticular injections; and limited for both pulsed radiofrequency and conventional radiofrequency neurotomy.
- Cervical Spine
- Evidence for therapeutic facet joint intervention is faire for conventional cervical radiofrequency neurotomy.
- Thoracic Spine
- Evidence is limited for radiofrequency neurotomy.
A number of radiofrequency generators and probes have been cleared for marketing through the U.S. Food and Drug Administration (FDA) 510(k) process.
See also medical policy 07.01.58 Facet Joint Denervation*
See also medical policy 07.01.66 Ablative Treatments for Occipital Neuralgia, Chronic Headaches and Atypical Facial Pain*
See also medical policy 07.01.73 Ablative Procedures of the Peripheral Nerves to Treat Pain*
Pulsed radiofrequency is considered investigational in the treatment of various pain syndromes including but not limited to the following:
- Headaches (including but not limited to the following: chronic headaches; cervicogenic headaches; migraines; cluster headaches; tension headaches)
- Chronic head and facial pain (persistent idiopathic facial pain (PIFP)/atypical facial pain)
- Neck pain (cervical pain)
- Occipital neuralgia
- Discogenic pain
- Low back pain
- Facet joint pain cervical, lumbar, and thoracic/Zygapophyseal joint pain
- Complex regional pain syndrome/reflex sympathetic dystrophy
- Pudenal neuralgia
- Sacro-iliac joint pain
- Trigeminal neuralgia
- Osteoarthritis of knee/chronic knee pain
- Osteoarthritis of hip/chronic hip pain
- Shoulder pain
- Thoracic pain
- Lumbo-sacral radicular syndrome
- Plantar fasciitis
- Morton’s neuroma
- Peripheral neuromas
- Tarsal tunnel syndrome
- Inguinal neuralgia
- Intercostal neuralgia
- Post-herpetic neuralgia
- Post herpetic itch
- Diabetic peripheral neuropathy
- Refractory ventricular arrhythmias
- Meralgia paresthetica
- Orchalgia (testicular pain)
- Ophthalmic neuralgia
Based on review of the peer reviewed medical literature the current available evidence on the effectiveness of pulsed radiofrequency (PRF) in the treatment of patients with various chronic pain syndromes is largely based on retrospective, case series studies. While some studies may have shown promising results for certain chronic pain syndromes, numerous studies yielded concerns about procedural protocols, study quality and patient follow up. Further well-designed, randomized controlled clinical trials with large sample size and long-term follow-up are needed to determine the therapeutic effect and safety of this treatment modality. Also, there currently is a lack data comparing pulsed radiofrequency with conventional treatments, and it is not known if pulsed radiofrequency offers any treatment advantage over other conventional treatments. In addition, there are no clinical practice guidelines from U.S. professional societies that recommend the use of pulsed radiofrequency. Per the 2013 ASIPP (American Society of Interventional Pain Physicians) their guidelines state “the evidence is limited for pulsed radiofrequency in the treatment of chronic spinal pain.” The evidence is insufficient to determine the safety and efficacy of pulsed radiofrequency (PRF) and is considered investigational for the treatment of pain from any cause.
Procedure Codes and Billing Guidelines:
To report provider services, use appropriate CPT* codes, Modifiers, Alpha Numeric (HCPCS level 2) codes, Revenue codes, and/or ICD diagnosis codes
- Cahana A, Van Zundert J, Macrea L et al. Pulsed radiofrequency: current clinical and biological literature available. Pain Med. 2006 Sep-Oct;7(5):411-23.
- Lindner R, Sluijter ME, Schleinzer W. Pulsed radiofrequency treatment of the lumbar medial branch for facet pain: a retrospective analysis. Pain Med. 2006 Sep-Oct;7(5):435-9.
- Tekin I, Mirzai H, Ok G et al. A comparison of conventional and pulsed radiofrequency denervation in the treatment of chronic facet joint pain. Clin J Pain. 2007 Jul-Aug;23(6):524-9.
- Van Zundert J, Patijun J, Kessels A et al. Pulsed radiofrequency adjacent to the cervical dorsal root ganglion in chronic cervical radicular pain: a double blind sham controlled randomized trial. Pain. 2007 Jan;127(1-2):173-82. Comment in: Expert Rev Neurother. 2007 May;7(5):471-2. Pain. 2007 Jan;127(1-2):3-4.
- Boswell MV, Trescot AM, Datta S et al. Interventional techniques: evidence-based practice guidelines in the management of chronic spinal pain. Pain Physician. 2007 Jan;10(1):7-111.
- Simopolous TT, Kraemer J, Nagda JV et al. Response to pulsed and continuous radiofrequency lesioning of the dorsal root ganglion and segmental nerves in patients with chronic lumbar radicular pain. Pain Physician. 2008 Mar;11(2):137-44.
- Luleci N, Ozdemir U, Dere K et al. Evaluation of patients’ response to pulsed radiofrequency treatment applied to the suprascapular nerve in patients with chronic shoulder pain. J Back Musculoskelet Rehabil. 2011 Jan 1; 24(3):189-94.
- Van Boxem K, van Bilsen J, de Meij N et al. Pulsed radiofrequency treatment adjacent to the lumbar dorsal root ganglion for the management of lumbosacral radicular syndrome: a clinical audit. Pain Med. 2011 Aug 3. doi:10.1111/j.1526-4637.2011.01202.x. [Epub ahead of print].
- Nagda JV, Davis CW, Bajwa ZH et al. Retrospective review of the efficacy and safety of repeated pulsed and continuous radiofrequency lesioning of the dorsal root ganglion/segmental nerve for lumbar radicular pain. Pain Physician. 2011 Jul-Aug; 14(4):371-6.
- Todorov L. Pulsed radiofrequency of the sural nerve for the treatment of chronic ankle pain. Pain Physician. 2011 May-Jun; 14(3):301-4.
- Korkmaz OK, Capaci K, Eyigor C et al. Pulsed radiofrequency versus conventional transcutaneous electrical nerve stimulation in painful shoulder: a prospective, randomized study. Clin Rehabil. 2010 Nov; 24(11):1000-8. Epub 2010 Aug 4.
- Taverner MG, Ward TL, Loughnan TE. Transcutaneous pulsed radiofrequency treatment in patients with painful knee awaiting total knee joint replacement. Clin J Pain. 2010 Jun;26(5):429-32.
- Eyigor C, Eyigor S, Korkmaz OK et al. Intra-articular corticosteroid injections versus pulsed radiofrequency in painful shoulder: a prospective, randomized, single-blinded study. Clin J Pain. 2010 Jun;26(5):386-92.
- Vanelderen P, Rouwette T, De Vooght P et al. Pulsed radiofrequency for the treatment of occipital neuralgia: a prospective study with 6 months of follow-up. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):148-51.
- Hansen H, Manchikanti L, Simopoulos TT et al. A systematic evaluation of the therapeutic effectiveness of sacroiliac joint interventions. Pain Physician. 2012 May-Jun; 15(3):E247-78.
- Gofeld M, Restrepo-Garces CE, Theodore BR et al. Pulsed radiofrequency of suprascapular nerve for chronic shoulder pain: a randomized double-blind active placebo-controlled study. Pain Pract. 2012 May 4. doi: 10.1111/j.1533-2500.2012.00560.x. [Epub ahead of print]
- Guo L, Kubat NJ, Nelson TR et al. Meta-analysis of clinical efficacy of pulsed radiofrequency energy treatment. Ann Surg. 2012 Mar; 255(3):457-67.
- Conner-Kerr T, Isenberg RA. Retrospective analysis of pulsed radiofrequency energy therapy use in the treatment of chronic pressure ulcers. Adv Skin Wound Care. 2012 Jun;25(6):253-60.
- Choi GS, Ahn SH, Cho YW et al. Short-term effects of pulsed radiofrequency on chronic refractory cervical radicular pain. Ann Rehabil Med. 2011 Dec;35(6):826-32. Epub 2011 Dec 30.
- Fukui S, Rohof O. Results of pulsed radiofrequency technique with two laterally placed electrodes in the annulus in patients with chronic lumbar discogenic pain. J Anesth. 2012 Aug;26(4):606-9. Epub 2012 Apr 5.
- Nagda JV, Davis CW, Bajwa ZH et al. Retrospective review of the efficacy and safety of repeated pulsed and continuous radiofrequency lesioning of the dorsal root ganglion/segmental nerve for lumbar radicular pain. Pain Physician. 2011 Jul-Aug;14(4):371-6.
- Werner MU, Bischoff JM, Rathmell JP et al. Pulsed radiofrequency in the treatment of persistent pain after inguinal herniotomy: a systematic review. Reg Anesth Pain Med. 2012 May-Jun;37(3):340-3.
- Zhang J, Shi DS, Wang R. Pulsed radiofrequency of the second cervical ganglion (C2) for the treatment of cervicogenic headache. J Headache Pain. 2011 Oct;12(5):569-71. Epub 2011 May 25.
- Manchikanti L, Abdi S et al. An update of comprehensive evidence-based guidelines for interventional techniques in chronic spinal pain. Part II. Pain Physician 2013 Apr; 16: S49-283.
- American Society of Anesthesiologists. Practice Guidelines for Chronic Pain Management: An Updated Report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine. Anesthesiology April 2010; 112: 1-1.
- National Institute of Health. NIH Public Access. Pulsed Radiofrequency for Chronic Pain, David Byrd M.D., MPH and Sean Mackey, M.D., PhD. January 2008; 12(1):37-41.
- Medscape Radiofrequency Therapies in Chronic Pain.
- Practical Pain Management Use of Pulsed Radiofrequency in Clinical Practice.
- Journal of Pain Research: Treatment of Trigeminal Neuralgia: Role of Radiofrequency Ablation. J Pain Res. 2010; 3:249-254. Published online December 12, 2010 doi:10.2147/JPRS14455
- PubMed. 3D-CT Guided Pulsed Radiofrequency Treatment for Trigeminal Neuralgia. Pain Practice.2014 Jan; 14(1):16-21. doi: 10.1111/papr.12041. Epub2013 Feb 21.
- Matthew David VanderHoek, Hieu T. Hoang, Brandon Goff, Ultrasound Guided Greater Occipital Nerve Blocks and Pulsed Radiofrequency Ablation for Diagnosis and Treatment of Occipital Neuralgia. Anesthesiology and Pain Medicine. 2013 September; 3(2):256-9.
- American Society of Interventional Pain Physicians (ASIPP). An Update of Comprehensive Evidence Based Guidelines for Interventional Techniques in Chronic Spinal Pain. Part II: Guidance and Recommendations. Pain Physicians 2013; 16:S49-S283 ISSN 1533-3159.
- American Pain Society. Guideline for Evaluation and Management of Low Back Pain, Evidence Review 2009.
- American Academy of Pain Medicine. Pulsed Radiofrequency Lesioning of Pudendal Nerve in Patient with Chronic Pain: A Case Report 2012.
- Pain Medicine News. Evidence Based Review of Radiofrequency Ablation Techniques for Chronic Sacroiliac Joint Pain.
- Pain Medicine News Special Edition December 2013, Pulsed Radiofrequency in Treatment of Peripheral Neuralgias
- Nicholas Manolitsis, M.D., Foad Elahi, M.D., Pulsed Radiofrequency for Occipital Neuralgia, Pain Physician 2014; 17:E709-E717.
- Slavin Konstantin, Nersesyan Hrachya et. al. Current Algorithm for the Surgical Treatment of Facial Pain, Head and Face Medicine July 2007
- American Society of Anesthesiologists and American Society of Regional Anesthesia and Pain Medicine, Practice Guideline for Chronic Pain Management, Anesthesiology 2010 Vol 112. No 4
- Medscape Radiofrequency Treatment in Chronic Pain, Expert Rev Neurother 2010;10(3):469-474.
- Akbas Mert Gunduz Emel, et.al. Sphenopalatine Ganglion Pulsed Radiofrequency Treatment in Patients Suffering from Chronic Face and Head Pain, April 2014
- Cohen S, Peterlin LB, Fulton L, et. al. Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness. Pain 2015 December; 156(12):2585-2594
- Taverner MG, Ward TL, Loughnan TE. Transcutaneous pulsed radiofrequency treatment in patients with painful knee awaiting total knee joint replacement. Clin J Pain. 2010;26(5):429-432
- Chua NH, Vissers KS, Sluijter ME. Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications – a review. Acta Neurochir (Wien). 2011 Apr 153(4):763-71
- Zakrzewska JM. Akram H. Neurosurgical interventions for the treatment of classical trigeminal neuralgia. Cochrane Database Syst Rev 2011 Sep 7(9): CD007312. PMID 21901707
- Taverner MG, Loughnan TE, Soon CW. Transcutaneous application of pulse radiofrequency treatment for shoulder pain. Pain Pract 2013 Apr 13(4):310-5
- Nagar VR, Birthi P, Grider JS, Asopa A. Systematic review of radiofrequency ablation and pulsed radiofrequency for management of cervicogenic headache. Pain Physician 2015 Mar-Apr 18(2):109-30. PMID 25794199
- van Boxem K, van Bilsen J, de Meij N, et. al. Pulsed radiofrequency treatment adjacent to the lumbar dorsal root ganglion for the management of lumbosacral radicular syndrome: A clinical audit. Pain Medicine 2011;12: 1322-1330
- Shanthanna H, Chan P, McChesney J, et. al. Pulsed radiofrequency treatment of the lumbar dorsal root ganglion in patients with chronic lumbar radicular pain: a randomized, placebo-controlled pilot study. Journal of Pain Research 2014:7 47-55
- Manolitsis N, Elahi F. Pulsed Radiofrequency for Occipital Neuralgia. Focused Review. Pain Physician 2014; 17: E709-E717
- Ke M, Yinghui F, Yi J, et. al. Efficacy of pulsed radiofrequency in the treatment of thoracic postherpatic neuralgia from the angulus costae: A randomized double blinded, controlled trial. Pain Physician 2013; 16:15-25
- Schianchi P, Sluijter M, Balogh S. The treatment of joint pain with intra-articular pulsed radiofrequency. Anesthesiology and Pain Medicine 2013 September;3(2):250-5
- Guo J, Dong X, Zhao X. Treatment of trigeminal neuralgia by radiofrequency of the Gasserian ganglion. Rev Neurosci 2016 Oct 1:27(7):739-743. PMID 27383870
- Hayase J, Vampola S, Ahadian F. et. la. Comparative efficacy of stellate ganglion block with bupivacaine vs pulsed radiofrequency in a patient with refractory ventricular arrhythmias. J Clin Anesth Jun 31;162-5. PMID 27185701
- Bhatia A, Peng P, Cohen SP. Radiofrequency procedures to relieve chronic knee pain: An evidence based narrative review. Reg Anesth Pain Med 2016 Jul-Aug;41(4):501-10. PMID 27281721
- Deniz S, Purtuloglu T, Tekindur S, et. al. Ultrasound guided pulsed radiofrequency treatment in Morton’s neuroma. J Am Podiatr Med Assoc 2015 Jul;105(4):302-6. PMID 25945935
- Makharita MY, Amr YM. Pulsed radiofrequency for chronic inguinal neuralgia. Pain Physician 2015 Mar-Apr;18(2):E147-55. PMID 25794213
- Nagar VR, Birthi P, Grider JS, et. al. Systematic review of radiofrequency ablation and pulsed radiofrequency for management of cervicogenic headache. Pain Physician 2015 Mar-Apr;18(2):109-30. PMID 25794199
- Kesikburun S, Yasar E, Uran A, et. al. Ultrasound guided genicular nerve pulsed radiofrequency treatment for painful knee osteoarthritis: A preliminary report. Pain Physician 2016;19:E751-E759.
- Naderi-Nabi B, Sedighinejad A, Haghighi M, et. al. Comparison of transcutaneous electrical nerve stimulation and pulsed radiofrequency sympathectomy for treating painful diabetic neuropathy. Anesth Pain Med 2015 October; 5(5):e29280
- Schianchi P. A new technique to treat facet joint pain with pulsed radiofrequency. Anesth Pain Med 2015 February; 5(1): e21061
- Akbas M, Gunduz E, Sanli S, et. al. Sphenopalatine ganglion pulsed radiofrequency treatment in patients suffering from chronic face and head pain. Bras Anestesiol vol. 66 no. 1 Campinas Jan/Feb 2016
- Chua NH, Vissers KC, Sluijter ME. Pulsed radiofrequency treatment in interventional pain management: Mechanisms and potential indications-a review. Acta Neurochir (Wien). 2011;153(4):763-771. PMID 21116663
- Choi HJ, Oh IH, Choi SK, Lim YJ. Clinical outcomes of pulsed radiofrequency neuromodulation for the treatment of occipital neuralgia. J Korean Neurosurg Soc. 2012;51(5):281-285. PMID 22792425
- Bui C, Pangarkar S, Zeitlin SI. Relief of urinary urgency, hesitancy, and male pelvic pain with pulse radiofrequency ablation of the pudendal nerve: A case presentation. Case Rep Urol. 2013;2013:125703. PMID 23607041
- Fang L, Ying S, Tao W, et al. 3D CT-guided pulsed radiofrequency treatment for trigeminal neuralgia. Pain Pract. 2014;14(1):16-21. PMID 23433058
- Kestranek J, Spacek J, Ryska P, et al. Radiofrequency therapy for severe idiopathic vulvodynia. J Low Genit Tract Dis. 2013;17(4):e1-e4. PMID 23903198
- Terkawi AS, Romdhane K. Ultrasound-guided pulsed radiofrequency ablation of the genital branch of the genitofemoral nerve for treatment of intractable orchalgia. Saudi J Anaesth. 2014;8(2):294-298. PMID 24843352
- Thapa D, Ahuja V. Combination of diagnostic medial calcaneal nerve block followed by pulsed radiofrequency for plantar fascitis pain: A new modality. Indian J Anaesth. 2014;58(2):183-185. PMID 24963184
- Park HG, Park PG, Kim WJ, et al. Ultrasound-assisted mental nerve block and pulsed radiofrequency treatment for intractable postherpetic neuralgia: Three case studies. Korean J Pain. 2014;27(1):81-85. PMID 24478907
- Eyigor C, Eyigor S, Akdeniz S, Uyar M. Effects of intra-articular application of pulsed radiofrequency on pain, functioning and quality of life in patients with advanced knee osteoarthritis. J Back Musculoskelet Rehabil. 2015;28(1):129-134. PMID 25061031
- Chon JY, Hahn YJ, Sung CH, et al. Pulsed radiofrequency under ultrasound guidance for the tarsal tunnel syndrome: Two case reports. J Anesth. 2014;28(6):924-927. PMID 24728720
- Ding DF, Li RC, Xiong QJ, et al. Pulsed radiofrequency to the great occipital nerve for the treatment of intractable postherpetic itch: A case report. Int J Clin Exp Med. 2014;7(10):3497-3500. PMID 25419389
- kbas M, Gunduz E, Sanli S, Yegin A. Sphenopalatine ganglion pulsed radiofrequency treatment in patients suffering from chronic face and head pain. Rev Bras Anestesiol. 2016;66(1):50-54. PMID 26768930
- Gulati A, Shah R, Puttanniah V, et al. A retrospective review and treatment paradigm of interventional therapies for patients suffering from intractable thoracic chest wall pain in the oncologic population. Pain Med. 2015;16(4):802-810. PMID 25236160
- De Andres J, Sanchis-Lopez N, Asensio-Samper JM, et al. Vulvodynia -- An evidence-based literature review and proposed treatment algorithm. Pain Pract. 2016;16(2):204-236. PMID 25581081
- Guo J, Dong X, Zhao X. Treatment of trigeminal neuralgia by radiofrequency of the Gasserian ganglion. Rev Neurosci. 2016;27(7):739-743. PMID 27383870
- Osman AM, El-Hammady DH, Kotb MM. Pulsed compared to thermal radiofrequency to the medial calcaneal nerve for management of chronic refractory plantar fasciitis: A prospective comparative study. Pain Physician. 2016;19(8):E1181-E1187. PMID 27906949
- Bhatjiwale MG, Bhatjiwale MM, Bhagat A. Ultra-extended euthermic pulsed radiofrequency for the treatment of ophthalmic neuralgia: A case report with elaboration of a new technique. Surg Neurol Int. 2016;7(Suppl 35):S818-S823. PMID 27990312
- Lee JJ, Sohn JH, Choi HJ, et al. Clinical efficacy of pulsed radiofrequency neuromodulation for intractable meralgia paresthetica. Pain Physician. 2016;19(3):173-179. PMID 27008291
- Gupta A, Huettner DP, Dukewich M. Comparative effectiveness review of cooled Versus pulsed radiofrequency ablation for the treatment of knee osteoarthritis: A systematic review. Pain Physician. 2017;20(3):155-171. PMID 28339430
- Weiss AL, Ehrhardt KP, Tolba R. Atypical facial pain: A comprehensive, evidence-based review. Curr Pain Headache Rep. 2017;21(2):8. PMID 28251523
- Cho IT, Cho YW, Kwak SG, Chang MC. Comparison between ultrasound-guided interfascial pulsed radiofrequency and ultrasound-guided interfascial block with local anesthetic in myofascial pain syndrome of trapezius muscle. Medicine (Baltimore). 2017;96(5):e6019. PMID 28151904
- Apiliogullari S, Gezer IA, Levendoglu F. Transient sensory recovery in stroke patients after pulsed radiofrequency electrical stimulation on dorsal root ganglia: A case series. Neurologist. 2017;22(1):18-20. PMID 28009767
- Facchini G, Spinnato P, Guglielmi G, et al. A comprehensive review of pulsed radiofrequency in the treatment of pain associated with different spinal conditions. Br J Radiol. 2017;90(1073):20150406. PMID 28186832
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