Treatment of Hyperhidrosis*

Medical Policy: 08.01.08 
Original Effective Date: January 2002 
Reviewed: December 2007 
Revised: March 2007 

This policy applies to all products unless specific contract limitations, exclusions or exceptions apply. Please refer to the member's coverage manual for benefit availability. Managed care guidelines related to referral authorization, and precertification of inpatient hospitalization, home health, home infusion and hospice services apply.


Description: 

Hyperhydrosis is excessive sweating, beyond a level required to maintain normal body temperature in response to heat exposure or exercise.  Hyperhydrosis can be classified as either primary or secondary. Primary hyperhidrosis is idiopathic in nature and typically involves the palmar surface of the hands, plantar surface of the feet, or the axillae. Secondary hyperhidrosis is the result of an underlying condition such as Parkinson's Disease, hyperthyroidism, diabetes mellitus, and hyperpituitarism. Certain drug classifications such as tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRI's) have been known to cause secondary hyperhidrosis.  Resolution of secondary hyperhidrosis involves treatment of the underlying cause or condition.

Thoracic sympathectomy is an invasive procedure intended to arrest the symptoms of hyperhidrosis. T2 sympathectomy is performed for patients with palmar hyperhidrosis and may significantly reduce foot sweating as well; while T3 and T4 sympathectomies are performed for those with axillary hyperhidrosis.  The procedures can be performed with either conventional electrocautery or laser.

Policy: 

Treatment of primary axillary, palmer, and plantar hyperhidrosis with botulinum toxin may be considered medically necessary only for patients with a significant functional impairment or medical complication who have failed to respond to conservative treatment. Conservative treatment includes topical dermatologics such as aluminum chloride, tannic acid, glutaraldehyde, anticholinergics or systemic medications such as anticholinergics, tranquilizers or non steroid anti-inflammatory drugs.

Treatment of primary hyperhidrosis with surgical excision of the axillary sweat glands may be considered medically necessary for patients who have failed to respond to conservative treatment.

Treatment of primary hyperhidrosis with thoracic sympathectomy* may be considered medically necessary when the following is met:

  • Documentation of 1 year of failed conservative medical treatments (e.g., topical therapy with aluminum chloride, systemic anticholinergics, botulinum toxin).

Prior approval is recommended only for thoracic sympathectomy. Submit a prior approval now.

Treatment of secondary hyperhidrosis with any of the above-mentioned approaches may be considered medically necessary only when treatment of the underlying cause of the hyperhidrosis has failed to relieve the symptoms and the symptoms continue to be severe and result in significant medical complications.

Treatment of primary hyperhidrosis with iontophoresis is considered investigational.

Treatment of primary hyperhidrosis with axillary liposuction is considered investigational.

Treatment of primary hyperhidrosis with thoracic sympathectomy in patients not meeting the above criteria is considered investigational.

Treatment of all forms of hyperhidrosis with any method described above in patients who do not meet the criteria described above is considered investigational. 


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Procedure Codes and Billing Guidelines: 

  • To report provider services, use appropriate CPT** codes, Alpha Numeric (HCPCS level 2) codes, Revenue codes, and/or ICD-9 diagnostic codes.
  • CPT 32664 to report endoscopy with thoracic sympathectomy.
  • CPT 64650 to report chemodenervation of eccrine glands; both axillae
  • CPT 64653 to report chemodenervation of eccrine glands; other area(s) (eg, scalp, face, neck), per day
  • HCPCS code J0585 to report botulinum toxin type A, per unit

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Selected References: 

  • Rajesh YS, Pratap CP, Woodyer AB. Thoracoscopic sympathectomy for palmar hyperhidrosis and Raynaud’s phenomenon of the upper limb and excessive facial blushing: a five year experience. Postgrad Med J 2002;78:682-684.
  • Leseche G, Castier Y, Thabut G, et al. Endoscopic transthoracic sympathectomy does not reduce postoperative compensatory sweating. Journal of Vascular Surgery, January 2003.
  • Atkinson JLD, Fealy RD, Sympathotomy Instead of Sympathectomy for Palmar Hyperhidrosis: Minimizing Postoperative Compensatory Hyperhidrosis. Mayo Clinic Proc. 2003;78:167-172.
  • Lin TS, KUO SJ, Chou MC. Uniportal Endoscopic Thoracic Sympathectomy For Treatment of Palmar and Axillary Hyperhidrosis: Analysis of 2000 Cases. Neurosurgery 51 [Suppl 2]:84-87, 2002.
  • Shelley WB, Talanin NY, Shelley ED. Botulinum toxin therapy for palmar hyperhidrosis. Journal of the American Academy of Dermatology 1998;38:227-229.
  • Sevim S, Dogu O, Kaleagasi H.  Botulinum toxin-A therapy for palmar and plantar hyperhidrosisActa Neurol Belg. 2002 Dec;102(4):167-70.
  • Vadoud-Seyedi J. Treatment of plantar hyperhidrosis with botulinum toxin type A.  Int J Dermatol. 2004 Dec;43(12):969-71. 
  • ECRI. Endoscopic Thoracic sympathectomy for Palmar hyperhidrosis.  Plymouth meeting (PA): ECRI Health Technology Information Service; 2004 July 9. 15p. (ECRI Hotline Response).
  • ECRI. Iontophoresis for Hyperhidrosis. Plymouth Meeting (PA): ECRI Health Technology Information Service; 2004 July 22. 7p. (ECRI Hotline Response).
  • ECRI. Botulinum Toxin for Treatment of Hyperhidrosis. Plymouth Meeting (PA): ECRI Health Technology Information Service; 2003 Sept. 40 p. Windows on Medical Technology; No. 99.
  • Baumgartner FJ, Toh Y. Severe hyperhidrosis: clinical features and current thoracoscopic surgical management. Ann Thorac Surg. 2003;76(6):1878-83.
  • Leseche G. Castier Y, Thabut G et al. Endoscopic transthoracic sympathectomy for upper limb hyperhidrosis: limited sympathectomy does not reduce postoperative compensatory sweating. J Vasc Surg. 2003;37(1):124-8. 

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New information or technology that would be relevant for Wellmark to consider when this policy is next reviewed may be submitted to:

Wellmark Blue Cross and Blue Shield
Medical Policy Analyst
Station 304
636 Grand Ave
Des Moines, Iowa 50309

*Prior Approval is recommended for this policy

**Current Procedural Terminology © 2008 American Medical Association. All Rights Reserved.

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