Contact Us
Plans and Services Health and Wellness About Wellmark Member Employer Producer Provider
Home Provider Medical Policies and Authorizations Alphabetical Listing


» Working with Wellmark.com
» News
» BlueCard®
» Claims and Payment
» Medical Policies and Authorizations
» Health Management
» Medical, Dental, and Pharmacy
» Credentialing and Contracting
» Quality and Transparency
» Communications and Resources
» Health Care Reform for Providers
printer friendly Printer-Friendly Page

Small Bowel Transplant*

» Summary» Procedure Codes
» Description» Selected References
» Prior Approval» Policy History
» Policy
 

Medical Policy: 07.03.04 
Original Effective Date: November 2009 
Reviewed: December 2014 
Revised: December 2014 


Benefit Application
Benefit determinations are based on the applicable contract language in effect at the time the services were rendered. Exclusions, limitations or exceptions may apply. Benefits may vary based on contract, and individual member benefits must be verified. Wellmark determines medical necessity only if the benefit exists and no contract exclusions are applicable. This medical policy may not apply to FEP. Benefits are determined by the Federal Employee Program.

This Medical Policy document describes the status of medical technology at the time the document was developed. Since that time, new technology may have emerged or new medical literature may have been published. This Medical Policy will be reviewed regularly and be updated as scientific and medical literature becomes available.


Description: 

Small bowel transplant has evolved into an established therapeutic modality in the management of the patient with irreversible intestinal failure. It is performed mainly in patients with short bowel syndrome (SBS) and those who develop severe complications due to total parenteral nutrition (TPN).  

 

Intestinal Failure is defined as the loss of absorptive capacity of the small bowel secondary to severe primary gastrointestinal disease or surgically induced short bowel syndrome. 

 

Short bowel syndrome is defined as an inadequate absorbing surface of the small intestine due to extensive disease or surgical removal of a large portion of small intestine.

 

Leading causes of intestinal failure differ between adult and pediatric populations. In children, the following are the leading causes of intestinal failure:

  • Intestinal atresia
  • Gastroschisis
  • Crohn disease
  • Microvillus involution disease
  • Necrotizing enterocolitis
  • Midgut volvulus
  • Chronic intestinal pseudo-obstruction
  • Massive resection secondary to tumor
  • Hirschsprung disease 

The following are the leading causes of intestinal failure in adults:

  • Crohn disease
  • Superior mesenteric artery thrombosis
  • Superior mesenteric vein thrombosis
  • Trauma
  • Desmoid Tumor
  • Volvulus
  • Pseudo-obstruction
  • Massive resection secondary to tumor
  • Radiation enteritis 

Total parenteral nutrition (TPN) is the current standard of care for patients with intestinal failure. The chronic use of TPN is often associated with life-threatening complications including:

  • Catheter related sepsis
  • Catheter related thrombosis
  • Severe dehydration
  • Parenteral nutrition associated liver disease (PNALD)

 Small bowel transplant should be recommended in patients with the following conditions:

 

1). Failure of parenteral nutrition
     • Impending or overt liver failure
     • Thrombosis of 2 or more central veins
     • Two ore more episodes per year of systemic sepsis secondary to line infections
     • Frequent episodes of dehydration

 

2). High risk of death

 

3). Severe short bowel syndrome (gastrotomy, duodenostomy, residual small bowel <10 cm in infants and <20 cm in adults)

 

4). Frequent hospitalization, narcotic dependency or pseudoobstruction

 

5). Unwillingness to accept long-term parenteral nutrition (TPN)

 

Small bowel transplant may be considered a means to avoid end stage liver failure, thus avoiding a multivisceral organ transplant.

 

Cadaveric small bowel transplant is the most commonly performed transplant, there has been recent interest in using living donors. Living donor transplantation has been proposed as a means to increase the pool of donor organs and thereby reduce waiting time and wait list morbidity and mortality.

 

Retransplantation
The most common causes of graft loss in small bowel transplant are infection, rejection (acute and chronic) and technical or clinical complications. Careful patient selection, post-transplant immunosuppression and patient management are essential for successful long term outcomes. Individuals undergoing repeat small bowel transplantation should meet all eligibility criteria and should not have contraindications to transplantation.   

 

Practice Guidelines or Position Statements

 

American Gastroenterological Association
In 2003, the American Gastroenterological Association produced a medical position statement on short bowel syndrome and intestinal transplantation. It recommends dietary, medical and surgical solutions. Indications for intestinal transplant mirror those of Medicare in patients who fail TPN therapy for one of the following reasons:

  • Impending or overt liver failure (increased serum bilirubin and/or liver enzyme levels, splenomegaly, thrombocytopenia, gastroesophageal varicies, coagulopathy, stomal bleeding, hepatic fibrosis or cirrhosis)
  • Thrombosis of central venous channels (2 thromboses in subclavian, jugular or femoral veins)
  • Frequent central line related  sepsis (2 episodes of systemic sepsis secondary to line infection per year, 1 episode of line related fungemia, septic shock, or acute respiratory distress syndrome).
  • Frequent severe dehydration.

 

Until better data become available, these parameters are likely to be widely recognized as the indications for intestinal transplantation. 


Top


Prior Approval: 

 

Prior approval is required. Submit a prior approval now.


Top


Policy: 

A small bowel transplant using a cadaveric intestine may be considered medically necessary in adult and pediatric patients with intestinal failure (characterized by loss of absorption and the inability to maintain protein-energy, fluid, electrolyte or micronutrient balance),  who have established long-term dependency on TPN and are developing or have developed severe complications due to TPN (see criteria above under Description).

 

Small bowel transplant using a living donor intestine may be considered medically necessary only when a cadaveric intestine is not available for transplantation in a patient who meets the above criteria for a cadaveric intestinal transplant.

 

Small bowel transplant using living donor is considered investigational in all other situations. Based on peer reviewed literature living donors for small bowel transplantation is limited and the number of living donor transplants performed to date has been small. The literature is mostly limited to single center individual case reports and small case series. More large studies are needed to determine impact on net health outcomes to include that patient survival is comparable or better than those patients receiving cadaveric organs. However, small bowel transplant using a living donor does have a role in select cases where a cadaveric intestine is not available, see above.

 

A small bowel transplant is considered not medically necessary for adults with intestinal failure who are able to tolerate TPN.

 

Small bowel transplant would be considered not medically necessary in those patients who are able to tolerate TPN, based on peer reviewed litereature small bowel transplant is indicated only in patients who have developed life-threatening complications attributable to their intestinal failure and/or long term TPN therapy.

 

Small bowel retransplantation may be considered medically necessary in individuals with graft failure of an initial small bowel transplant who meet criteria for small bowel transplantation. 

 

Except as defined above, candidates for small bowel transplant should meet the following general criteria:

  • Adequate cardiopulmonary status
  • Absence of active infection
  • Documentation of patient compliance with medical management 

The evaluation of a transplant candidate who has a history of cancer must consider the prognosis and risk of recurrence from available information including tumor type and stage, response to therapy, and time since therapy was completed. Although evidence is limited, patients in whom cancer is thought to be cured should not be excluded from consideration for transplant. UNOS has not addressed malignancy in current policies.

 

The United Network for Organ Sharing (UNOS) believes that asymptomatic HIV-positive patients should not necessarily be excluded for candidacy for organ transplantation, stating, “A potential candidate for organ transplantation whose test for HIV is positive but who is in an asymptomatic state should not necessarily be excluded from candidacy for organ transplantation, but should be advised that he or she may be at increased risk of morbidity and mortality because of immunosuppressive therapy.” In 2001, the Clinical Practice Committee of the American Society of Transplantation proposed that the presence of AIDS could be considered a contraindication to kidney transplant unless the following criteria were present. These criteria may be extrapolated to other potential organ transplants:

  • CD4 count ≥ 200 cells/mm-3 for > 6 months
  • HIV-1 RNA undetectable
  • On stable anti-retroviral therapy > 3 months
  • No other complications from AIDS (e.g., opportunistic infection including aspergillus, tuberculosis, coccidioses mycosis, resistant fungal infections, Kaposi’s sarcoma, or other neoplasm)
  • Meeting all other criteria for organ transplantation 

It is likely that each individual transplant center will have explicit patient selection criteria for HIV-positive patients.





Top


Procedure Codes and Billing Guidelines: 

  • To report provider services, use appropriate CPT* codes, Modifiers, Alpha Numeric (HCPCS level 2) codes, Revenue codes, and/or diagnosis codes.
  • 44135 Intestinal allotransplantation; from cadaver donor
  • 44136 Intestinal allotransplantation from living donor

Top


Selected References: 

  • Steinman TI, Becker BN, Frost AE et al. Guidelines for the referral and management of patients eligible for solid organ transplantation. Transplantation 2001; 71(9):1189-204.
  • O’Keefe SJ, Buchman AL, Fishbein TM et al. Short bowel syndrome and intestinal failure: consensus definitions and overview. Clin Gastroenterol Hepatol 2006; 4(1): 6-10.
  • American Gastroenterological Association. American Gastroenterological Association medical position statement: short bowel syndrome and intestinal transplantation. Gastroenterology. 2003 Apr;124(4):1105-10.
  • Tzvetanov IG, Oberholzer J, Benedetti E. Current status of living donor small bowel transplantation. Curr Opin Organ Transplant. 2010 Jun;15(3):346-8.
  • Gangemi A, Tzvetanov IG, Beatty E et al. Lessons learned in pediatric small bowel and liver transplantation from living-related donors. Transplantation. 2009 Apr 15;87(7):1027-30.
  • Giuliana Testa, M.D., Fabrizio Panaro, M.D., Stefano Schena, M.D., Mark Holterman, M.D., Herand Abcarian, M.D. and Enrico Benedetti, M.D. Annals of Surgery, 2004 November; 240(5); 779-784. Living Related Small Bowel Transplantation. 
  •   CMS. National Coverage Determination (NCD) for Intestinal and Multi-Visceral Transplantation (260.5).
  • UpToDate. Overview of Intestinal an Multivisceral Transplantation. Farrukh A. Khan, M.D., FACS, Gennaro Selvaggi, M.D. Topic last updated October 18, 2012.
  • Medscape. Intestinal Transplantation. Stuart M. Greenstein, M.D. Updated March 5, 2012.
  • Medscape. Pediatric Intestinal and Multivisceral Transplantation. Seigo Nishida, M.D., PhD. Updated May 30, 2012.
  • UpToDate. Overview of Intestinal and Multivisceral Transplantation. Farrukh A Khan, M.D., FACS, Gennaro Selvaggi, M.D., Topic last updated April 11, 2014. Also available at www.uptodate.com
  • UpToDate. Management of the Short Bowel Syndrome in Children. John A. Vanderhoof, M.D., Rosemary J. Pauley-Hunter, NP-C, MS, RN. Topic last updated June 12, 2014. Also available at www.uptodate.com
  • Management of the Short Bowel Syndrome in Adults. Jon A. Vanderhoof, M.D., Rosemary J. Pauley-Hunter, NP-C, MS, RN. Topic last updated August 21, 2014. Also available at www.uptodate.com
  • Medscape. Stuart M. Greestein, M.D. et. al. Intestinal Transplantation, updated August 17, 2014. Also available at http://emedicine.medscape.com/article/1013245
  • Organ Procurement and Transplant Network, Allocation of Livers and Liver-Intestines. Also available at http://optn. Transplant.hrsa.gov
  • Organ Procurement and Transplant Network, Intestine, Also available at http://optn.transplant.hrsa.gov
  • PubMed. Intestinal and Multivisceral Retransplantation Results: Literature Review. Transplant Proc. 2013 Apr:45(3):1133-6.

Top


Policy History: 

 

Date                                        Reason                               Action

April 2011                              Annual review                     Policy revised

March 2012                           Annual review                     Policy renewed

March 2013                           Annual review                     Policy renewed

February 2014                       Annual review                     Policy revised

December 2014                     Annual review                     Policy revised


Top


Wellmark medical policies address the complex issue of technology assessment of new and emerging treatments, devices, drugs, etc.   They are developed to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. Wellmark medical policies contain only a partial, general description of plan or program benefits and do not constitute a contract. Wellmark does not provide health care services and, therefore, cannot guarantee any results or outcomes. Participating providers are independent contractors in private practice and are neither employees nor agents of Wellmark or its affiliates. Treating providers are solely responsible for medical advice and treatment of members. Our medical policies may be updated and therefore are subject to change without notice.

*Current Procedural Terminology © 2012 American Medical Association. All Rights Reserved.

 
Contact Information
New information or technology that would be relevant for Wellmark to consider when this policy is next reviewed may be submitted to:
  Wellmark Blue Cross and Blue Shield
  Medical Policy Analyst
  P.O. Box 9232
  Des Moines, IA 50306-9232
FacebookTwitterInstagrampinterestLinked InYou Tube